Foster, RJ orcid.org/0000-0002-5337-3615, Damion, RA, Ries, ME orcid.org/0000-0002-8050-3200 et al. (3 more authors) Activation Energy Mapping in Articular Cartilage. In: Medical Engineering Centres Annual Meeting and Bioengineering 14, 10-11 Sep 2014, Imperial College, London.
Abstract
Magnetic resonance imaging of articular cartilage has, in the past, had a primary focus on clinical, qualitative imaging or quantitative mapping purely using relaxation times (e.g. T1 and T2) and the development of phenomenological models to link these to physical properties, such as GAG content. Recent work in the field has looked at more advanced imaging methods, such as dGEMRIC, gagCEST and diffusion tensor imaging in order to attempt to develop a more direct link to physical and biochemical properties of the cartilage. This link is important to further understand the structure and function of cartilage, and here we investigate a novel method to probe the physical and biochemical properties of cartilage tissue.
We present a novel method for visualising cartilage using magnetic resonance imaging techniques, which have been developed for probing the structure, mobility and hydration of soft-matter systems. This approach has been used to determine the dynamic activation energy (EA) of water within articular cartilage. Two related imaging methods have been explored: firstly quantitative mapping of the T1-relaxation time over a range of temperatures and secondly, quantitative mapping of the apparent diffusion coefficient over a range of temperatures. These are complementary techniques that probe the local tissue environment by extracting the rotational activation energy of the water within articular cartilage from the T1-relaxation time mapping, and the translational activation energy from the apparent diffusion coefficient mapping.
These methods have been shown to provide different information from within the articular cartilage tissue to that seen with other imaging techniques. These quantitative maps can provide a link to biochemical contents or physical properties of articular cartilage tissue and can be interpreted in terms of the known structure and properties of cartilage from other methods.
Metadata
Item Type: | Conference or Workshop Item |
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Authors/Creators: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Soft Matter Physics (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Experimental Musculoskeletal Medicine (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 088908/Z/09/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Jul 2019 14:01 |
Last Modified: | 12 Jul 2019 14:10 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:95630 |