Chen, J, Kong, Y, Wang, W et al. (6 more authors) (2016) Direct Water-phase Synthesis of Lead Sulfide Quantum Dots Encapsulated by β-Lactoglobulin for In Vivo Second Near Infrared Window Imaging with Reduced Toxicity. Chemical Communications, 52. pp. 4025-4028. ISSN 1359-7345
Abstract
Compared to traditional fluorescence imaging in the visible and NIR-I regions (700-900 nm), second near infrared window (NIR-II, 1000-1400 nm)-based optical imaging offers reduced photon scattering, deeper tissue penetration and lower auto-fluorescence. Despite the excellent imaging capabilities, current NIR-II probes have not yet reached their full potential for biomedical imaging applications due to weak quantum yields, low water solubility and suboptimal biocompatibility. To address these factors, NIR-II fluorescent PbS quantum dots (QDs) encapsulated by β-lactoglobulin (LG) are conveniently prepared via a one-pot microwave-assisted synthesis. The as-prepared LG-PbS QDs feature excellent aqueous dispersibility, high quantum yield and favorable biocompatibility. In vivo imaging experiments show that LG-PbS QDs are superbly suitable for real-time and high-resolution in vivo imaging; these features make these QDs extremely promising for use in various bioimaging applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, Royal Society of Chemistry. This is an author produced version of a paper published in Chemical Communications. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Quantum dot; NIR-II window; Lead sulfide; In vivo imaging; protein template |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/J501475/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Mar 2016 11:17 |
Last Modified: | 12 Apr 2017 10:27 |
Published Version: | http://dx.doi.org/10.1039/C6CC00099A |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C6CC00099A |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:95463 |