Lucas, SJ, Lord, RM, Basri, AM et al. (4 more authors) (2016) Increasing Anti-Cancer Activity with Longer Tether Lengths of Group 9 Cp* Complexes. Dalton Transactions, 45 (16). pp. 6812-6815. ISSN 1477-9226
Abstract
Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2016. This is an author produced version of a paper published in Dalton Transactions. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Feb 2016 10:52 |
Last Modified: | 11 Apr 2017 05:33 |
Published Version: | http://dx.doi.org/%2010.1039/C6DT00186F |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C6DT00186F |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:95274 |