Gotham, V.J., Hobbs, M.C., Burgin, R. et al. (3 more authors) (2016) Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay. Organic & Biomolecular Chemistry, 14 (5). pp. 1559-1563. ISSN 1477-0520
Abstract
During efforts to prepare the known compound , a new tetracyclic compound, called , was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
| Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) UNSPECIFIED CYSTIC FIBROSIS TRUST RS 33 WELLCOME TRUST (THE) 092401/Z/10/Z CANCER RESEARCH UK (CRUK) C10338/A3855 CANCER RESEARCH CAMPAIGN (PLS USE CANCER RESEARCH UK) C10338/A3855 MEDICAL RESEARCH COUNCIL None |
| Depositing User: | Symplectic Sheffield |
| Date Deposited: | 18 Feb 2016 09:24 |
| Last Modified: | 18 Feb 2016 09:24 |
| Published Version: | https://dx.doi.org/10.1039/c5ob02482j |
| Status: | Published |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Identification Number: | 10.1039/c5ob02482j |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:95218 |
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