Karawajczyk, A, Giordanetto, F, Benningshof, J et al. (8 more authors) (2015) Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective. Drug Discovery Today, 20 (11). pp. 1310-1316. ISSN 1878-5832
Abstract
High-throughput screening (HTS) represents a major cornerstone of drug discovery. The availability of an innovative, relevant and high-quality compound collection to be screened often dictates the final fate of a drug discovery campaign. Given that the chemical space to be sampled in research programs is practically infinite and sparsely populated, significant efforts and resources need to be invested in the generation and maintenance of a competitive compound collection. The European Lead Factory (ELF) project is addressing this challenge by leveraging the diverse experience and know-how of academic groups and small and medium enterprises (SMEs) engaged in synthetic and/or medicinal chemistry. Here, we describe the novelty, diversity, structural complexity, physicochemical characteristics and overall attractiveness of this first batch of ELF compounds for HTS purposes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Mar 2016 11:56 |
Last Modified: | 11 Apr 2018 15:51 |
Published Version: | http://dx.doi.org/10.1016/j.drudis.2015.09.009 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.drudis.2015.09.009 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94995 |