Liu, G, Jiang, Y and Wang, X (2015) Tailoring Particle Microstructures Via Supercritical CO2 Processes for Particular Drug Delivery. Current Pharmaceutical Design, 21 (19). pp. 2543-2562. ISSN 1873-4286
Abstract
Strategies for a particular drug delivery are always of great interest to the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures. Combining with research experiences in our research group, this review aims to provide a roadmap of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties (administration methods, drug release behaviour and targeting) are directly influenced by the particle microstructures (morphology, particle size, particle size distribution, crystal form, drug loading, encapsulation efficiency, etc). “Inverse” strategies are introduced at first to obtain the necessary particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focusing on the screening and selection of operating parameters according to thermodynamic and fluid dynamic studies. Recent examples of SCF micronization and co-precipitation/encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters. Finally, challenges and issues needing further study are briefly suggested for SCD PD. - See more at: http://www.eurekaselect.com/130373/article#sthash.ghBUkP32.hbmORVav.dpuf
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, Bentham Science Publishers. This is an author produced version of a paper published in Current Pharmaceutical Design. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Supercritical fluids; drug delivery; particle design; microstructures; process; operating parameters; thermodynamics; fluid dynamics |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Mar 2016 12:13 |
Last Modified: | 02 Jul 2016 00:56 |
Published Version: | http://dx.doi.org/10.2174/138161282166615041610111... |
Status: | Published |
Publisher: | Bentham Science Publishers |
Identification Number: | 10.2174/1381612821666150416101116#sthash.ghBUkP32.6hC84yHv.dpuf |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94952 |