Turner, NA orcid.org/0000-0002-4957-5433 (2011) Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways. Future Cardiology, 7 (5). pp. 673-691. ISSN 1479-6678
Abstract
Cardiac fibroblasts are key players in the myocardial remodeling process and respond to myocardial damage or dysfunction by adopting a myofibroblast phenotype and undergoing increased proliferation, migration, secretion of bioactive molecules and turnover of the extracellular matrix. Many of the key cellular responses of the heart to injury or stress are mediated via specific signaling cascades involving the stress-activated protein kinases (SAPKs). The SAPKs comprise the p38 MAPK and c-Jun N-terminal kinase families, both of which have been implicated in promoting myocardial damage and adverse cardiac remodeling. This article focuses on SAPK signaling cascades in the heart, with particular emphasis on their modulatory effects on cardiac fibroblast function, inflammation and fibrosis. It also describes current and future therapeutic strategies for inhibiting SAPKs in the myocardium. Understanding the role of SAPK signaling at the cellular level holds potential for developing novel therapies to ameliorate cardiac dysfunction in man.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © Future Medicine . This is an author produced version of a paper published in Future Cardiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | cardiac fibroblast; JNK; myocardial remodeling; p38; stress-activated protein kinase; therapeutic agents |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 May 2019 13:30 |
Last Modified: | 10 May 2019 13:30 |
Status: | Published |
Publisher: | Future Medicine |
Identification Number: | 10.2217/fca.11.41 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94845 |