TEARE, M.D. orcid.org/0000-0003-3994-0051, WALLACE, S.A., HARRIS, M. et al. (2 more authors) (1994) Cancer experience in the relatives of an unselected series of breast cancer patients. British Journal of Cancer, 70 (1). pp. 102-111. ISSN 0007-0920
Abstract
First- and second-degree relatives of an unselected series of 402 breast cancer patients have been studied for their cancer experience. In the first-degree relatives an excess of all cancers is seen [overall relative risk (RR) = 1.28, P = 0.002; males RR = 1.26, P = 0.047; females RR = 1.30, P = 0.022). There is a marked excess of sarcoma (RR = 4.26, P = 0.0064); females are at high risk of breast cancer (RR = 2.68, P < 0.0001) and males have an excess of carcinoma of the lip, oral cavity and pharynx (RR = 4.22, P = 0.0032). Second-degree relatives have a non-significant excess of all cancers (RR = 1.14, P = 0.14); females have a borderline excess of breast cancer (RR = 1.53, P = 0.08) and an excess of carcinoma of the kidney (RR = 7.46, P = 0.0012) and males have an excess of carcinoma of the trachea and lung (RR = 1.50, P = 0.032). No excess of prostate or ovarian carcinoma was seen. Relatives are at slightly higher risk if the index patient is diagnosed between the ages of 40 and 49 (first-degree RR = 1.64, P = 0.007; second-degree RR = 1.43, P = 0.02). The excess of cancers, including breast cancers, is not limited to a few high-risk families, but appears to be spread across many. These observations may be accounted for by shared environmental factors within families or a common predisposing gene with low penetrance.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1994 Macmillan Press Ltd. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | SOFT-TISSUE SARCOMA; GERMLINE MUTATIONS; RISK; FAMILIES; LINKAGE; INHERITANCE; CHILDREN; GENE; CHROMOSOME-17Q; TRANSMISSION |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 Sep 2016 13:24 |
Last Modified: | 28 Sep 2016 13:24 |
Published Version: | http://dx.doi.org/10.1038/bjc.1994.257 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/bjc.1994.257 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94494 |
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