Johnson, DC, Weinhold, N, Mitchell, J et al. (18 more authors) (2016) Genetic factors influencing the risk of multiple myeloma bone disease. Leukemia, 30 (4). pp. 883-888. ISSN 0887-6924
Abstract
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totaling 3774), which had been radiologically surveyed for MBD. Each patient had been genotyped for ~6 00 000 single-nucleotide polymorphisms with genotypes for six million common variants imputed using 1000 Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio=1.38, P=4.09 × 10-9) and a promising association at 19q13.43 (rs74676832, odds ratio=1.97, P=9.33 × 10-7). Our findings demonstrate that germline variation influences MBD and highlights the importance of RANK/RANKL/OPG pathway in MBD development. These findings will contribute to the development of future strategies for prevention of MBD in the early precancerous phases of MM.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Clinical Trials Research (LICTR) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Feb 2016 13:24 |
Last Modified: | 21 Nov 2018 13:44 |
Published Version: | http://dx.doi.org/10.1038/leu.2015.342 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/leu.2015.342 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94467 |