Dondas, HA, Hempshall, A, Narramore, S et al. (3 more authors) (2016) γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5- component cascades. Tetrahedron, 72 (10). pp. 1316-1329. ISSN 0040-4020
Abstract
γ-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5- component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce γ-carboline based HDAC inhibitors.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2016, Elsevier Ltd. This is an author produced version of a paper published in Tetrahedron. Uploaded in accordance with the publisher's self-archiving policy. |
| Keywords: | γ-Carbolines, palladium catalysed, HDAC inhibitor, uridine allene, cascade chemistry |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 28 Jan 2016 16:40 |
| Last Modified: | 21 Jan 2017 20:58 |
| Published Version: | http://dx.doi.org/10.1016/j.tet.2016.01.025 |
| Status: | Published |
| Publisher: | Elsevier |
| Identification Number: | 10.1016/j.tet.2016.01.025 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94325 |
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