Gibson, J.F. and Johnston, S.A. (2015) Immunity to Cryptococcus neoformans and C. gattii during cryptococcosis. Fungal Genetics and Biology, 78. pp. 76-86. ISSN 1087-1845
Abstract
The vast majority of infection with cryptococcal species occurs with Cryptococcus neoformans in the severely immunocompromised. A significant exception to this is the infections of those with apparently normal immune systems by Cryptococcus gattii. Susceptibility to cryptococcosis can be broadly categorised as a defect in adaptive immune responses, especially in T cell immunity. However, innate immune cells such as macrophages play a key role and are likely the primary effector cell in the killing and ultimate clearance of cryptococcal infection. In this review we discuss the current state of our understanding of how the immune system responds to cryptococcal infection in health and disease, with reference to the work communicated at the 9th International Conference on Cryptococcus and Cryptococcosis (ICCC9). We have focussed on cell mediated responses, particularly early in infection, but with the aim of presenting a broad overview of our understanding of immunity to cryptococcal infection, highlighting some recent advances and offering some perspectives on future directions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Cryptococcus neoformans; Cryptococcus gattii; Cryptococcosis; Macrophages; T cells; Immunity |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL C0494 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Jan 2016 17:32 |
Last Modified: | 26 Jan 2016 17:32 |
Published Version: | https://dx.doi.org/10.1016/j.fgb.2014.11.006 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.fgb.2014.11.006 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94292 |