Busquets, J, Lee, Y, Santamarina, L et al. (5 more authors) (2013) Acute retinal artery occlusion in systemic sclerosis: A rare manifestation of systemic sclerosis fibroproliferative vasculopathy. Seminars in Arthritis and Rheumatism, 43 (2). pp. 204-208. ISSN 0049-0172
Abstract
Objectives: To describe three patients with systemic sclerosis (SSc) who developed acute unilateral blindness in the absence of any common etiologic factor for blindness. In one patient, the affected eye required enucleation and was examined histopathologically. Methods: Following identification of the first patient with retinal artery occlusion at the Scleroderma Center of Thomas Jefferson University, every patient evaluated at the Center from May 2001 to December 2010 was prospectively assessed for the development of acute unilateral blindness. Two additional cases were identified. Here, we describe the clinical features, laboratory and ancillary examinations of the three patients with SSc who developed acute unilateral blindness and present the histopathological examination of one eye enucleated from one of the patients. Results: Clinical and angiographic studies were consistent with acute retinal artery occlusion. The histopathological studies showed severe retinal ischemic atrophy and concentric narrowing and fibrosis of small retinal vessels. Conclusions: These findings suggest that acute retinal artery occlusion in these patients is a manifestation of the fibroproliferative vasculopathy characteristic of SSc.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Systemic sclerosis; Scleroderma; Acute retinal artery occlusion; Fibroproliferative vasculopathy; Endothelial cell |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Experimental Musculoskeletal Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Jul 2016 15:32 |
Last Modified: | 04 Nov 2016 00:18 |
Published Version: | http://doi.org/10.1016/j.semarthrit.2012.12.025 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.semarthrit.2012.12.025 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:93994 |