McGonagle, D, Aydin, SZ, Gul, A et al. (2 more authors) (2015) 'MHC-I-opathy'-unified concept for spondyloarthritis and Behcet disease. Nature Reviews Rheumatology, 11 (12). pp. 731-740. ISSN 1759-4804
Abstract
The spondyloarthropathies comprise ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis (PsA) and arthritis associated with inflammatory bowel disease. In this Perspectives article, we describe how Behçet disease and several clinically distinct spondyloarthropathies—all associated with MHC class I (MHC-I) alleles such as HLA-B*51, HLA-C*0602 and HLA-B*27 and epistatic ERAP-1 interactions—have a shared immunopathogenetic basis. As a unifying concept, we propose that barrier dysfunction in environmentally exposed organs such as the skin, and aberrant innate immune reactions at sites of mechanical stress, can often trigger secondary adaptive immune CD8+ T-cell responses with prominent neutrophilic inflammation that culminate in exacerbation and recurrence of these diseases. Of note, these 'MHC-I-opathies' show a differential immunopathology, probably reflecting antigenic differences within target tissues: HLA-B*51 is linked to ocular and mucocutaneous disease but not gut involvement, and HLA-C*0602 is linked to type I psoriasis but not scalp or nail disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Disease genetics; Immunopathogenesis; Spondyloarthritis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Experimental Musculoskeletal Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jun 2016 15:21 |
Last Modified: | 25 Jun 2016 14:13 |
Published Version: | http://dx.doi.org/10.1038/nrrheum.2015.147 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/nrrheum.2015.147 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:93937 |