Gul, HL, Ferreira, JF and Emery, P (2015) Remission in rheumatoid arthritis: is it all the same? Expert Review of Clinical Pharmacology, 8 (5). pp. 575-586. ISSN 1751-2433
Abstract
Remission is the key treatment goal in rheumatoid arthritis and should provide the optimal state for patients. Clinical remission criteria are based on composite scores of disease activity and are widely used in clinical practice and trials. With the use of biologic therapies and treat to target strategies, rates of clinical remission have significantly improved. Despite achieving this target, many patients demonstrate structural and functional deterioration. This raises the question regarding the validity of clinical criteria, although they have evolved significantly over the years. Imaging modalities such as ultrasound have been described as more accurate methods of assessing the remission state compared with clinical assessment alone. Furthermore, immuno-pathological assessments are gaining significant interest as this would enable assessment of disease activity at the primary site of pathology. Further research is required to develop accurate biomarkers of remission. We aimed to review the evolution of remission criteria in rheumatoid arthritis to date and to evaluate novel concepts in and the future of defining remission.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Biomarkers; classification criteria; comprehensive disease control; disease-modifying anti-rheumatic drugs; remission; rheumatoid arthritis; T-cell immunology; ultrasound |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Clinical Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Sep 2016 15:13 |
Last Modified: | 04 Nov 2016 07:27 |
Published Version: | http://dx.doi.org/10.1586/17512433.2015.1061429 |
Status: | Published |
Publisher: | Expert Reviews |
Identification Number: | 10.1586/17512433.2015.1061429 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:93865 |