Yang, Y., Rowen, D., Brazier, J. et al. (3 more authors) (2015) An Exploratory Study to Test the Impact on Three "Bolt-On" Items to the EQ-5D. Value In Health, 18 (1). pp. 52-60. ISSN 1098-3015
Abstract
Background
Generic preference-based measures were criticized for being inappropriate in some conditions. One solution is to include “bolt-on” dimensions describing additional specific health problems.
Objectives
This study aimed to develop bolt-on dimensions to the EuroQol five-dimensional questionnaire (EQ-5D) and assess their impact on health state values.
Methods
Bolt-on dimensions were developed for vision problems, hearing problems, and tiredness. Each bolt-on dimension had three severity levels to match the EQ-5D. Three “core” EQ-5D states across a range of severity were selected, and each level of a bolt-on item was added, resulting in nine states in each condition. Health states with and without the bolt-on dimensions were valued by 300 members of the UK general public using time trade-off in face-to-face interviews, and mean health state values were compared using t tests. Regression analysis examined the impact of the bolt-on variants and the level of the bolt-on items after controlling for sociodemographic characteristics.
Results
Bolt-on dimensions had an impact on health state values of the EQ-5D; however, the size, direction, and significance of the impact depend on the severity of the core EQ-5D state and of the bolt-on dimension. Regression analysis demonstrated that after controlling for possible differences in sociodemographic characteristics between the groups, there were no significant differences in health state values between the three bolt-on dimensions but confirmed that the impact depended on the severity of the EQ-5D health state and the levels of bolt-on dimensions.
Conclusions
The impact of a bolt-on dimension on the EQ-5D depends on the core health state and the level of the bolt-on dimension. Further research in this area is encouraged.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, International Society for Pharmacoeconomics and Outcomes Research (ISPOR). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
Keywords: | bolt-on; EQ-5D; health state valuation; hearing; tiredness; vision |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research The University of Sheffield > Faculty of Social Sciences (Sheffield) > Department of Economics (Sheffield) |
Funding Information: | Funder Grant number BRUNEL UNIVERSITY R29130 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jan 2016 12:32 |
Last Modified: | 18 Jan 2016 12:32 |
Published Version: | http://dx.doi.org/10.1016/j.jval.2014.09.004 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jval.2014.09.004 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:93835 |