Al-Kharobi, H, El-Gendy, R, Devine, DA et al. (1 more author) (2014) The role of the insulin‑like growth factor (IGF) axis in osteogenic and odontogenic differentiation. Cellular and Molecular Life Sciences, 71 (8). pp. 1469-1476. ISSN 1420-682X
Abstract
The insulin-like growth factor (IGF) axis is a multicomponent molecular network which has important biological functions in the development and maintenance of differentiated tissue function(s). One of the most important functions of the IGF axis is the control of skeletal tissue metabolism by the finely tuned regulation of the process of osteogenesis. To achieve this, the IGF axis controls the activity of several cell types—osteoprogenitor cells, osteoblasts, osteocytes and osteoclasts to achieve the co-ordinated development of appropriate hard tissue structure and associated matrix deposition. In addition, there is an increasing awareness that the IGF axis also plays a role in the process of odontogenesis (tooth formation). In this review, we highlight some of the key findings in both of these areas. A further understanding of the role of the IGF axis in hard tissue biology may contribute to tissue regeneration strategies in cases of skeletal tissue trauma.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Insulin-like growth factor axis, Osteogenesis, Odontogenesis, Differentiation, Dental pulp |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Apr 2016 08:04 |
Last Modified: | 04 Apr 2016 08:04 |
Published Version: | http://dx.doi.org/10.1007/s00018-013-1508-9 |
Status: | Published |
Publisher: | Springer |
Identification Number: | 10.1007/s00018-013-1508-9 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:93364 |