A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance
Tomlinson, JH, Thompson, GS, Kalverda, AP et al. (2 more authors)
(2016)
A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.
Scientific Reports, 6.
p. 19524.
ISSN 2045-2322
Abstract
Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding of FusB to EF G induces conformational and dynamic changes in the latter, shedding light on the molecular mechanism of fusidic acid resistance.
Metadata
Item Type:
Article
Authors/Creators:
Tomlinson, JH
Thompson, GS
Kalverda, AP
Zhuravleva, A
O'Neill, AJ
Copyright, Publisher and Additional Information:
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords:
Drug resistance; antibacterial; elongation factor-G; NMR
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