Rodriguez-Marin, S, Murphy, N, Shepherd, HJ et al. (1 more author) (2015) Design, Synthesis and Conformational Analyses of Bifacial Benzamide Based Foldamers. RSC Advances, 5 (126). pp. 104187-104192. ISSN 2046-2069
Abstract
The design, synthesis and conformational analyses of novel backbones represents a key focus of research that underpins efforts to exploit foldamers (i) in a biological setting e.g. as inibitors of protein-protien interations (PPIs) and (ii) for the purposes of constructing functional architectures that adopt defined teriary and quarternary folds. The current manuscirpt addresses a need to develop aromatic oligoamide backbones that are regiosiomeric in terms of backbone connectivity and/or functionalized on more than one face. We describe the design, synthesis and comparative conformational analyses of foldamers derived from 2-, 3- and 2,5-O-alkylated derivatives of para-aminobenzoic acid, and, derived from 2-,3- and 2,5-O-alkyalted derivatives of 1,4-diaminobenzene/terephthalic acid monomers. Analysis of the accessible conformational space for these oligomers indicates that despite different connectivity they can adopt conformations that position side chains in a manner that mimic the i, i + 3, i + 4 of an α-helix.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, The Royal Society of Chemistry. This is an author produced version of a paper accepted for publication in RSC Advances. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Dec 2015 12:49 |
Last Modified: | 23 Nov 2016 23:14 |
Published Version: | http://dx.doi.org/10.1039/C5RA20451H |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C5RA20451H |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:92887 |