Bosutti, A, Egginton, S, Barnouin, Y et al. (3 more authors) (2015) Local capillary supply in muscle is not determined by local oxidative capacity. Journal of Experimental Biology, 218 (21). 3377 - 3380. ISSN 0022-0949
Abstract
It is thought that the prime determinant of global muscle capillary density is the mean oxidative capacity. However, feedback control during maturational growth or adaptive remodelling of local muscle capillarisation is likely to be more complex than simply matching O2 supply and demand in response to integrated tissue function. We tested the hypothesis that the maximal oxygen consumption (MO2,max) supported by a capillary is relatively constant, and independent of the volume of tissue supplied (capillary domain). We demonstrate that local MO2,max assessed by succinate dehydrogenase histochemistry: (1) varied more than 100-fold between individual capillaries and (2) was positively correlated to capillary domain area in both human vastus lateralis (R=0.750, P<0.001) and soleus (R=0.697, P<0.001) muscles. This suggests that, in contrast to common assumptions, capillarisation is not primarily dictated by local oxidative capacity, but rather by factors such as fibre size, or consequences of differences in fibre size such as substrate delivery and metabolite removal.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, The Authors. Published by The Company of Biologists Ltd. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | succinate dehydrogenase, capillarisation, muscle, capillary domains |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Dec 2015 15:34 |
Last Modified: | 18 Sep 2016 00:38 |
Published Version: | http://dx.doi.org/10.1242/jeb.126664 |
Status: | Published |
Publisher: | Company of Biologists |
Identification Number: | 10.1242/jeb.126664 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:92667 |