Bromfield, Stephen M. and Smith, David K. orcid.org/0000-0002-9881-2714 (2015) Heparin versus DNA:Chiral preferences in polyanion binding to self-assembled multivalent (SAMul) nanostructures. Journal of the American Chemical Society. pp. 10056-10059. ISSN 1520-5126
Abstract
This communication presents simple cationic self-assembling multivalent (SAMul) first generation dendrons based on l or d lysine, which form identical nanoscale assemblies in terms of dimensions and charge densities but toward which DNA and heparin exhibit different chiral binding preferences. However, higher generation dendrons with larger hydrophilic head groups are bound identically by these polyanions, irrespective of chirality. We propose that well-organized chiral ligands on the surface of self-assembled nanostructures can exhibit enantioselective polyanion binding. This demonstrates that small structural changes can be amplified by self-assembly and impact on nanoscale binding.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © American Chemical Society 2015. This content is made available by the publisher under a Creative Commons CC BY Licence |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York |
Depositing User: | Pure (York) |
Date Deposited: | 10 Dec 2015 13:26 |
Last Modified: | 21 Jan 2025 17:18 |
Published Version: | https://doi.org/10.1021/jacs.5b04344 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/jacs.5b04344 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:92627 |
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