Crowther, G and Wilcox, MH (2015) Antibiotic therapy and clostridium difficile infection – primum non nocere – first do no harm. Infection and Drug Resistance, 8. 333 - 337. ISSN 1178-6973
Abstract
Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually nosocomial infection posing an urgent threat to public health. A major paradox of the management of CDI is the use of antimicrobial agents to treat infection, which runs the risk of prolonged gut microbiota perturbation and so recurrence of infection. Here, we explore alternative CDI treatment and prevention options currently available or in development. Notably, strategies that aim to reduce the negative effects of antibiotics on gut microbiota offer the potential to alter current antimicrobial stewardship approaches to preventing CDI.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, Crowther and Wilcox. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
Keywords: | Treatment; prevention; CDI; SYN-004; vaccine; beta-lactams |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Dec 2015 11:21 |
Last Modified: | 12 Feb 2019 13:19 |
Published Version: | http://dx.doi.org/10.2147/IDR.S87224 |
Status: | Published |
Publisher: | Dove Medical Press |
Identification Number: | 10.2147/IDR.S87224 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:92557 |
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