Pearsall, SM, Rowley, CN and Berry, A (2015) Advances in Pathway Engineering for Natural Product Biosynthesis. CHEMCATCHEM, 7 (19). 3078 - 3093. ISSN 1867-3880
Abstract
Biocatalysts provide an efficient, inexpensive and environmentally friendly alternative to traditional organic synthesis, especially for compounds with complex stereochemistries. The past decade has seen a significant rise in the use of biocatalysts for the synthesis of compounds in an industrial setting; however, the incorporation of single enzymatically catalysed steps into organic synthesis schemes can be problematic. The emerging field of synthetic biology has sparked interest in the development of whole-cell factories that can convert simple, common metabolites into complex, high-value molecules with a range of applications such as pharmaceuticals and biofuels. This Review summarises conventional methods and recent advances in metabolic engineering of pathways in microorganisms for the synthesis of natural products.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2015 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. This is the accepted version of the following article: Pearsall, SM, Rowley, CN and Berry, A (2015) Advances in Pathway Engineering for Natural Product Biosynthesis. CHEMCATCHEM, 7 (19). 3078 - 3093, which has been published in final form at http://dx.doi.org/10.1002/cctc.201500602. |
Keywords: | biosynthesis; natural products; pathway engineering; synthetic biology; synthesis design |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Nov 2015 11:18 |
Last Modified: | 16 Nov 2016 08:37 |
Published Version: | http://dx.doi.org/10.1002/cctc.201500602 |
Status: | Published |
Publisher: | Wiley-VCH Verlag |
Identification Number: | 10.1002/cctc.201500602 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:92158 |