Stadnicka-Michalak, Julita, Schirmer, Kristin and Ashauer, Roman orcid.org/0000-0002-9579-8793 (2015) Toxicology across scales:Cell population growth in vitro predicts reduced fish growth. Science Advances. e1500302. ISSN 2375-2548
Abstract
Environmental risk assessment of chemicals is essential but often relies on ethically controversial and expensive methods. We show that tests using cell cultures, combined with modeling of toxicological effects, can replace tests with juvenile fish. Hundreds of thousands of fish at this developmental stage are annually used to assess the influence of chemicals on growth. Juveniles are more sensitive than adult fish, and their growth can affect their chances to survive and reproduce. Thus, to reduce the number of fish used for such tests, we propose a method that can quantitatively predict chemical impact on fish growth based on in vitro data. Our model predicts reduced fish growth in two fish species in excellent agreement with measured in vivo data of two pesticides. This promising step toward alternatives to fish toxicity testing is simple, inexpensive, and fast and only requires in vitro data for model calibration.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2015 The Authors. This content is made available by the publisher under a Creative Commons CC-BY Licence |
Keywords: | fish, toxicokinetics, toxicodynamics, growth, in vitro cell line, TK-TD model |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Environment and Geography (York) |
Depositing User: | Pure (York) |
Date Deposited: | 28 Oct 2015 10:05 |
Last Modified: | 16 Oct 2024 12:40 |
Published Version: | https://doi.org/10.1126/sciadv.1500302 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1126/sciadv.1500302 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:90835 |
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Description: 42 Toxicology across scales