Md Yusof, MY, Vital, EM and Buch, MH (2015) B Cell Therapies, Approved and Emerging: a Review of Infectious Risk and Prevention During Use. Current Rheumatology Reports, 17 (10). 65. ISSN 1523-3774
Abstract
The development of B cell-targeted biologics represents a major advance in the treatment of autoimmune rheumatic diseases. As with other immunosuppressive agents, risk of infection is a key clinical concern. This review summarises safety data from 15 years of experience of rituximab in autoimmune diseases with a particular focus on opportunistic infection and class-specific complications and infection risk. Rarely, cases of progressive multifocal leucoencephalopathy in rituximab-treated patients (5/100 000) have accumulated over time although no proven causal association has yet been shown. With repeat cycles of therapy, hypogammaglobulinaemia has been observed in a larger proportion of patients and is associated with increased risk of serious infections. The infection profile of the newer B cell-targeted agent, belimumab, in patients with active systemic lupus erythematosus is also discussed. Data from registries are needed to extend insights further and also to evaluate for any impact with the difference in mode of action of belimumab and infection risk in this population.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, Springer. This is an author produced version of a paper published in Current Rheumatology Reports. Uploaded in accordance with the publisher's self-archiving policy. The final publication is available at Springer via http://dx.doi.org/10.1007/s11926-015-0539-7. |
Keywords: | B cell; Belimumab; Immunoglobulin; infection; Rituximab; rheumatic diseases |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Clinical Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Sep 2015 08:21 |
Last Modified: | 26 Oct 2016 10:57 |
Published Version: | http://dx.doi.org/10.1007/s11926-015-0539-7 |
Status: | Published |
Publisher: | Current Medicine Group |
Identification Number: | 10.1007/s11926-015-0539-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:90288 |