Khuphe, M, Mukonoweshuro, B, Kazlauciunas, A et al. (1 more author) (2015) A Vegetable Oil-Based Organogel for use in pH-Mediated Drug Delivery. Soft Matter, 11. 9160 - 9167. ISSN 1744-683X
Abstract
Organogels prepared with vegetable oils as the liquid organic phase present an excellent platform for the controlled delivery of hydrophobic guest molecules. We disclose a graft copolymer comprised of a poly(l-serine) backbone linked to alkane side-chains by hydrolytically susceptible ester bonds, that is capable of gelating edible safflower oil. The thermoresponsive organogel formed, which is non-cytotoxic, is capable of withholding guest molecules before undergoing targeted disassembly upon incubation in solutions of acidic pH, permitting the directed release of payload molecules. The presented material offers an extremely promising candidate for the controlled delivery of hydrophobic agents within acidic environments, such as cancer tumour sites.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2015. This is an author produced version of a paper published in Soft Matter. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Colour Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Sep 2015 14:02 |
Last Modified: | 25 Oct 2016 05:24 |
Published Version: | http://dx.doi.org/10.1039/C5SM02176F |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C5SM02176F |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:90216 |