Conway, C, Graham, JL, Chengot, P et al. (6 more authors) (2015) Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq. Oncotarget, 6 (37). pp. 40186-40201.
Abstract
Oral squamous cell carcinoma (OSCC) is a prevalent cancer with poor prognosis. Most OSCC progresses via a non-malignant stage called dysplasia. Effective treatment of dysplasia prior to potential malignant transformation is an unmet clinical need. To identify markers of early disease, we performed RNA sequencing of 19 matched HPV negative patient trios: normal oral mucosa, dysplasia and associated OSCC. We performed differential gene expression, principal component and correlated gene network analysis using these data. We found differences in the immune cell signatures present at different disease stages and were able to distinguish early events in pathogenesis, such as upregulation of many HOX genes, from later events, such as down-regulation of adherens junctions. We herein highlight novel coding and non-coding candidates for involvement in oral dysplasia development and malignant transformation, and speculate on how our findings may guide further translational research into the treatment of oral dysplasia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2015, The Authors. This is an open access article licensed under a Creative Commons Attribution 3.0 License. |
Keywords: | RNAseq, Oral Squamous Cell Carcinoma, OSCC, Dysplasia, Non-coding |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust No Ext Ref Given Yorkshire Cancer Research UNKNOWN |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Sep 2015 09:29 |
Last Modified: | 23 Jun 2023 21:52 |
Published Version: | http://dx.doi.org/10.18632/oncotarget.5529 |
Status: | Published |
Publisher: | Impact Journals |
Identification Number: | 10.18632/oncotarget.5529 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:89632 |