Dwivedi, M., Kemp, E.H., Laddha, N.C. et al. (3 more authors) (2015) Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics. Autoimmunity Reviews, 14 (1). 49 - 56. ISSN 1873-0183
Abstract
Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes. Regulatory T cells (Tregs) are crucial to the development of self-tolerance and so are major foci in the study of autoimmune pathogenesis of vitiligo. This review will summarise recent findings concerning the role of Tregs in the pathogenesis of vitiligo. In addition, as antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, new strategies that expand or induce de novo generation of Tregs and which are currently being investigated as therapies for other autoimmune diseases, will be discussed. These approaches will highlight the opportunities for Treg cell-based therapeutics in vitiligo.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2014 Elsevier B.V. This is an author produced version of a paper subsequently published in Autoimmunity Reviews. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | Autoimmunity; CD8+ T cells; Melanocyte; Pigmentation; Regulatory T cells; Vitiligo |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Oct 2015 15:42 |
Last Modified: | 25 Oct 2016 21:08 |
Published Version: | http://dx.doi.org/10.1016/j.autrev.2014.10.002 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.autrev.2014.10.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:89614 |