Kirby, A orcid.org/0000-0002-2440-9316, Hassan, I and Burnie, J (2006) Recommendations for managing Aspergillus osteomyelitis and joint infections based on a review of the literature. Journal of Infection, 52 (6). pp. 405-414. ISSN 0163-4453
Abstract
Objectives: To produce recommendations for the management of Aspergillus osteomyelitis and joint infections. Methods: Published literature was surveyed to identify both case reports of Aspergillus osteomyelitis and joint infections and anti-fungal pharmacology of anti-fungal agents. Included in the pharmacological review was an assessment of new and investigational anti-fungals to consider their potential role in the management of this infection. Results: Successful treatments, identified from the cases reviewed, were based on combination anti-fungal therapy with one agent having good bone penetration and one having reliable anti-Aspergillus activity. Conclusions: For the management of serious Aspergillus osteomyleitis/joint infections amphotericin B in combination with flucytosine is recommended. A number of second line treatment combinations are identified. Monotherapy is appropriate with an azole in clinically stable patients.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Aspergillus; Osteomyelitis; Anti-fungal therapy |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Sep 2017 15:20 |
Last Modified: | 06 Sep 2017 15:20 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jinf.2005.08.016 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:89363 |