Stark, D, Bowen, D, Dunwoodie, E et al. (5 more authors) (2015) Survival patterns in teenagers and young adults with cancer in the United Kingdom: Comparisons with younger and older age groups. European Journal of Cancer, 51 (17). pp. 2643-2654. ISSN 0959-8049
Abstract
Aims: We aimed to describe and compare survival in teenagers and young adults (TYAs) with cancer to that of younger children and older adults, to identify sub-populations at greater or lesser risk of death. Methods: We compared survival in cancer patients diagnosed in the United Kingdom aged 13-24 years (TYAs) to those aged 0-12 (children) and 25-49 years (adults) using the National Cancer Data Repository. All cases had a first cancer diagnosis between 1st January 2001 and 31st December 2005 with censor date 31st December 2010 or death if earlier. Results: We found six distinct statistically significant survival patterns. In pattern 1, the younger the age-group the better the 1- and 5-year survival (acute lymphoid leukaemia, carcinoma of ovary and melanoma). In pattern 2, TYAs had a worse 5-year survival than both children and young adults (bone and soft tissues sarcomas). In pattern 3, TYAs had a worse 1-year survival but no difference at 5-years (carcinoma of cervix and female breast). In pattern 4, TYAs had better 1-year survival than adults, but no difference at 5 years (carcinoma of liver and intrahepatic bile ducts, germ cell tumours of extra-gonadal sites). In pattern 5, the younger the age-group the better the 5-year survival, but the difference developed after 1-year (acute myeloid leukaemia, carcinoma of colon and rectum). In pattern 6, there was no difference in 1- and 5-year survival between TYAs and adults (testicular germ cell tumours, ovarian germ cell tumours and carcinoma of thyroid). Conclusion: TYAs with specific cancer diagnoses can be grouped according to 1- and 5-year survival patterns compared to children and young adults. To further improve survival for TYAs, age-specific biology, pharmacology, proteomics, genomics, clinician and patient behaviour studies embedded within clinical trials are required.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2015, Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in European Journal of Cancer. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Adolescent; young adult; teenage; neoplasms; survival analysis; cancer survival; teenager and young adult cancer; central nervous system tumours; Haematogical malignancies; Bone tumours |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Funding Information: | Funder Grant number Candlelighters No Ext Ref Given Cancer Research UK C24098/A9294 Candlelighters NOT GIVEN National Inst for Health Research (NIHR) PB-PG-1207-15237 Teenage Cancer Trust No Ext Ref Given National Inst for Health Research (NIHR) TYA CAN COHORT STY G569 EU - European Union 261747 EU - European Union 261747 |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Aug 2015 13:31 |
Last Modified: | 29 Oct 2016 12:41 |
Published Version: | http://dx.doi.org/10.1016/j.ejca.2015.08.010 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ejca.2015.08.010 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:89177 |