Marsh, PD, Do, T, Beighton, D et al. (1 more author) (2016) Influence of saliva on the oral microbiota. Periodontology 2000, 70 (1). pp. 80-92. ISSN 0906-6713
Abstract
Saliva plays a major role in determining the composition and activity of the oral microbiota, via a variety of mechanisms. Molecules, mainly from saliva, form a conditioning film on oral surfaces, thus providing receptors for bacterial attachment. The attached cells use saliva components, such as glycoproteins, as their main source of nutrients for growth. Oral bacteria work sequentially and in a concerted manner to catabolize these structurally complex molecules. Saliva also buffers the pH in the biofilm to around neutrality, creating an environment which is conducive to the growth of many oral bacteria that provide important benefits to the host. Components of the adaptive and innate host defences are delivered by saliva, and these often function synergistically, and at sublethal concentrations, so a complex relationship develops between the host and the resident microbiota. Dysbiosis can occur rapidly if the flow of saliva is perturbed.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2015, Wiley. This is the peer reviewed version of the following article: "Marsh, P. D., Do, T., Beighton, D. and Devine, D. A. (2016), Influence of saliva on the oral microbiota. Periodontology 2000, 70: 80–92.", which has been published in final form at http://dx.doi.org/10.1111/prd.12098. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | Saliva; microbial attachment; pellicle; host defences; host defence peptides; glycoproteins |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Jan 2016 10:47 |
Last Modified: | 09 Mar 2016 00:43 |
Published Version: | http://dx.doi.org/10.1111/prd.12098 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/prd.12098 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88911 |