Griffin, S orcid.org/0000-0002-7233-5243 (2014) “Too little, too late?” Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic? Future Medicinal Chemistry, 6 (17). pp. 1893-1907. ISSN 1756-8919
Abstract
Hepatitis C virus (HCV) p7 is a virus-coded ion channel, or 'viroporin'. p7 is an essential HCV protein, promoting infectious virion production, and this process can be blocked by prototypic p7 inhibitors. However, prototype potency is weak and effects in clinical trials are unsatisfactory. Nevertheless, recent structural studies render p7 amenable to modern drug discovery, with studies supporting that effective drug-like molecules should be achievable. However, burgeoning HCV therapies clear infection in the majority of treated patients. This perspective summarizes current understanding of p7 channel function and structure, pertaining to the development of improved p7 inhibitors. We ask, 'is this too little, too late', or could p7 inhibitors play a role in the long-term management of HCV disease?
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Oncology and Cancer Research - Labs (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jun 2016 13:25 |
Last Modified: | 24 Jun 2016 13:25 |
Published Version: | http://dx.doi.org/10.4155/fmc.14.121 |
Status: | Published |
Publisher: | Future Science |
Identification Number: | 10.4155/fmc.14.121 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88839 |