Lassila, T., Lange, M., Porras, A.R. et al. (4 more authors) (2016) Electrophysiology Model for a Human Heart with Ischemic Scar and Realistic Purkinje Network. In: STACOM 2015, 9 October 2015, MICCAI 2015, Munich, Germany.
Abstract
The role of Purkinje fibres in the onset of arrhythmias is controversial and computer simulations may shed light on possible arrhythmic mechanisms involving the Purkinje fibres. However, few computational modelling studies currently include a detailed Purkinje network as part of the model. We present a coupled Purkinje-myocardium electrophysiology model that includes an explicit model for the ischemic scar plus a detailed Purkinje network, and compare simulated activation times to those obtained by electro-anatomical mapping in vivo during sinus rhythm pacing. The results illustrate the importance of using sufficiently dense Purkinje networks in patient-specific studies to capture correctly the myocardial early activation that may be influenced by surviving Purkinje fibres in the infarct region.
Metadata
Item Type: | Conference or Workshop Item |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Springer International Publishing Switzerland. This is an author produced version of a paper subsequently published in Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Electronic and Electrical Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Jan 2016 11:05 |
Last Modified: | 19 Apr 2017 07:59 |
Published Version: | http://dx.doi.org/10.1007/978-3-319-28712-6_10 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1007/978-3-319-28712-6_10 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88812 |