Cardoso, B.A., Girio, A., Henriques, C.M. et al. (4 more authors) (2008) Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications. Brazilian Journal of Medical and Biological Research, 41 (5). pp. 344-350. ISSN 0100-879X,
Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-beta, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the correct stratification of patients into appropriate therapeutic regimens and to identify novel targets for the development of specific, less detrimental therapies for T-ALL.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2008 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | T-cell acute lymphoblastic leukemia; Notch; PI3K/Akt; MAPK; Jak/STAT; TGF-ß |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Aug 2015 16:59 |
Last Modified: | 20 Aug 2015 16:59 |
Published Version: | http://dx.doi.org/10.1590/S0100-879X2008005000016 |
Status: | Published |
Publisher: | Associação Brasileira de Divulgação Científica |
Refereed: | Yes |
Identification Number: | 10.1590/S0100-879X2008005000016 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88712 |