Jiang, LH, Mortadza, SAS, Wang, L et al. (1 more author) (2015) TRPM2 channel-mediated ROS-sensitive Ca2+ signaling mechanisms in immune cells. Frontiers in Immunology, 6 (407). ISSN 1664-3224
Abstract
Transient receptor potential melastatin 2 (TRPM2) proteins form Ca2+-permeable cationic channels that are potently activated by reactive oxygen species (ROS). ROS are produced during immune responses as signaling molecules as well as anti-microbial agents. ROS-sensitive TRPM2 channels are widely expressed in cells of the immune system and located on the cell surface as a Ca2+ influx pathway in macrophages, monocytes, neutrophils, lymphocytes and microglia but preferentially within the lysosomal membranes as a Ca2+ release mechanism in dendritic cells; ROS activation of the TRPM2 channels, regardless of the subcellular location, results in an increase in the intracellular Ca2+ concentrations. Recent studies have revealed that TRPM2-mediated ROS-sensitive Ca2+ signaling mechanisms play a crucial role in a number of processes and functions in immune cells. This mini-review discusses the recent advances in revelation of the various roles the TRPM2 channels have in immune cell functions and the implications in inflammatory diseases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 Syed Mortadza, Wang, Li and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. |
Keywords: | TRPM2; reactive oxygen species; Ca2+ signaling; immune cell functions; inflammatory diseases |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Oct 2015 09:36 |
Last Modified: | 25 Oct 2015 21:50 |
Published Version: | http://dx.doi.org/10.3389/fimmu.2015.00407 |
Status: | Published |
Publisher: | Frontiers |
Identification Number: | 10.3389/fimmu.2015.00407 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88623 |