Lotfi, S, Patel, AS, Mattock, K et al. (3 more authors) (2013) Towards a more relevant hind limb model of muscle ischaemia. Atherosclerosis, 227 (1). pp. 1-8. ISSN 0021-9150
Abstract
Critical limb ischaemia is a severe manifestation of peripheral arterial disease characterised by intractable pain and tissue gangrene. Conventional treatments include percutaneous angioplasty and surgical bypass but up to one third of patients are not amenable to these interventions and will ultimately require amputation. Therapeutic neovascularisation has been proposed as an alternative treatment in these 'no option' patients and both cytokines and cells have shown impressive efficacy in the laboratory. Clinical trials in man, however, have had modest results. This discrepancy has put into question the relevance of the pre-clinical assays that are used to test potential agents. One of the most widely used of these assays is the hind limb ischaemia model that is often performed in young, healthy animals. This review critiques the techniques used to induce and assess ischaemia in this model and outlines the reasons why healthy rodents cannot fully recapitulate critical limb ischaemia in aged patients. Strategies that may produce a hind limb model that better simulates the human condition are proposed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Therapeutic angiogenesis; Angiogenesis; Hind limb ischaemia; Peripheral arterial disease; Critical limb ischaemia |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Aug 2016 14:34 |
Last Modified: | 03 Nov 2016 05:13 |
Published Version: | http://doi.org/10.1016/j.atherosclerosis.2012.10.0... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.atherosclerosis.2012.10.060 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88468 |