Wragg, JW, Durant, S, McGettrick, HM et al. (3 more authors) (2014) Shear stress regulated gene expression and angiogenesis in vascular endothelium. Microcirculation, 21 (4). 290 - 300. ISSN 1073-9688
Abstract
The behavior of vascular EC is greatly altered in sites of pathological angiogenesis, such as a developing tumor or atherosclerotic plaque. Until recently it was thought that this was largely due to abnormal chemical signaling, i.e., endothelial cell chemo transduction, at these sites. However, we now demonstrate that the shear stress intensity encountered by EC can have a profound impact on their gene expression and behavior. We review the growing body of evidence suggesting that mechanotransduction, too, is a major regulator of pathological angiogenesis. This fits with the evolving story of physiological angiogenesis, where a combination of metabolic and mechanical signaling is emerging as the probable mechanism by which tight feedback regulation of angiogenesis is achieved in vivo.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Wragg JW, Durant S, McGettrick HM, Sample KM, Egginton S, Bicknell R. Shear stress regulated gene expression and angiogenesis in vascular endothelium. Microcirculation 21: 290–300, 2014, which has been published in final form at http://dx.doi.org/10.1111/micc.12119. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | angiogenesis; atherosclerosis; cancer; eNOS; endothelial cells; mechanotransduction; shear stress; vasculature; Animals; Endothelium, Vascular; Gene Expression Regulation; Humans; Neovascularization, Physiologic; Shear Strength; Signal Transduction; Stress, Physiological |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Oct 2015 11:03 |
Last Modified: | 12 Apr 2017 00:50 |
Published Version: | http://dx.doi.org/10.1111/micc.12119 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/micc.12119 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88459 |