Wight, T.N., Kinsella, M.G. and Qwarnström, E.E. orcid.org/0000-0003-4417-8663 (1992) The role of proteoglycans in cell adhesion, migration and proliferation. Current Opinion in Cell Biology, 4 (5). 793 - 801. ISSN 0955-0674
Abstract
Proteoglycans comprise a part of the extracellular matrix that participates in the molecular events that regulate cell adhesion, migration and proliferation. Their structural diversity and tissue distribution suggest a functional versatility not generally encountered for other extracellular matrix components. This versatility is mainly dictated by their molecular interactions and their ability to regulate the activity of key molecules involved in several biological events. This molecular cooperativity either promotes or inhibits cell adhesion, migration and proliferation. A growing number of studies indicate that proteoglycans can play a direct role in these cellular events by functioning either as receptors or as ligands for molecules that are required for these events to occur. Such studies support a role for proteoglycans as important effectors of cellular processes that constitute the basis of development and disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright Current Biology Ltd, ISSN 0955-0674 |
Keywords: | Animals; Cell Adhesion; Cell Division; Cell Movement; Humans; Proteoglycans |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Department of Cardiovascular Science |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 01 Oct 2015 15:25 |
Last Modified: | 24 Jul 2018 12:48 |
Published Version: | https://doi.org/10.1016/0955-0674(92)90102-I |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/0955-0674(92)90102-I |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88381 |