Kirby, A and Santoni, N (2015) Antibiotic resistance in Enterobacteriaceae: What impact on the efficacy of antibiotic prophylaxis in colorectal surgery? Journal of Hospital Infection, 89 (4). 259 - 263. ISSN 0195-6701
Abstract
Antibiotic prophylaxis, introduced in the 1940s, brought in an era of relatively safe colorectal surgery. This was achieved in part due to the prevention of surgical site infections (SSIs) caused by Enterobacteriaceae. Since then, Enterobacteriaceae have become increasingly resistant to the antibiotics commonly used for prophylaxis. The impact of being colonized preoperatively with resistant Enterobacteriaceae on the efficacy of colorectal SSI prophylaxis, if any, is unknown. It is also difficult to predict the likely impact of resistance as the exposure-response relationships have not been determined for antibiotic surgical prophylaxis. Neither is it known which test for resistance to use; the importance of the concentration of Enterobacteriaceae in the colon, the ability of different species of Enterobacteriaceae to cause SSIs, and the comparative ability of minimum inhibitory concentration or presence of a resistance mechanism in predicting SSI risk have yet to be established. Clinical research is urgently needed to answer these questions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, The Healthcare Infection Society. Published by Elsevier Ltd.This is an author produced version of a paper published in Journal of Hospital Infection. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Colorectal; Enterobacteriaceae; Prophylaxis; resistance; surgical site infection |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Oct 2015 10:58 |
Last Modified: | 11 Apr 2017 09:21 |
Published Version: | http://dx.doi.org/10.1016/j.jhin.2014.11.016 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jhin.2014.11.016 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88330 |