Chan, DSM, Bandera, EV, Greenwood, DC et al. (1 more author) (2015) Circulating C-reactive protein and breast cancer risk – systematic literature review and meta-analysis of prospective cohort studies. Cancer Epidemiology, Biomarkers and Prevention, 24 (10). 1439 - 1449. ISSN 1055-9965
Abstract
We conducted a systematic literature review to explore the association between circulating C-reactive protein (CRP), a low-grade inflammation biomarker, and breast cancer risk. Relevant prospective studies in women were identified in PubMed and Web of Science until February 2015. Random-effects dose-response metaanalysis was conducted, overall and in post-menopausal women. Twelve out of 15 studies identified were included in the meta-analysis on any breast cancers (3,522 cases, 69,610 women) and nine on postmenopausal breast cancer (2,516 cases, 36,847 women). For each doubling of CRP concentration, a 7% (95% CI: 2%–12%) and 6% (95% CI: 1%–11%) increased risk was observed (I2=47% and 32%; P heterogeneity=0.04 and 0.17), respectively. The association was linear over most of the range of CRP concentrations. Positive associations remained in the studies that examined the exclusion of early years of follow-up. Associations were attenuated in studies adjusted for lifestyle factors, which partly explained the significant heterogeneity between studies in the overall analysis. On average, the associations in studies adjusted or not adjusted for body mass index were similar. Low-grade inflammation may have a role in breast cancer development. Additional prospective studies are needed to better understand confounding and effect modification from lifestyle factors.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, American Association for Cancer Research. This is an author produced version of a paper published in Cancer Epidemiology, Biomarkers and Prevention. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Jul 2015 11:37 |
Last Modified: | 04 Nov 2017 20:54 |
Published Version: | http://dx.doi.org/10.1158/1055-9965.EPI-15-0324 |
Status: | Published |
Publisher: | American Association for Cancer Research |
Identification Number: | 10.1158/1055-9965.EPI-15-0324 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88289 |