Bunn, B., Hunter, K., Khurram, S.A. et al. (1 more author) (2014) Adenoid dysplasia of the oral mucosa. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 118 (5). 586 - 592. ISSN 2212-4403
Abstract
Objective
To describe an unusual variant of oral epithelial dysplasia and to provide an appraisal of its immunohistochemical profile.
Study Design
An unusual form of epithelial dysplasia, which we have termed adenoid dysplasia, was evaluated for staining of cytokeratins AE1/AE3, vimentin, E-cadherin, and β-catenin. The immunohistochemical results were compared with those observed in moderate epithelial dysplasia, moderately differentiated squamous cell carcinoma, and acantholytic squamous cell carcinoma.
Results
The immunoprofile of adenoid dysplasia was similar to that of acantholytic squamous cell carcinoma. Cytokeratin positivity within the acantholytic dysplastic cells confirmed their epithelial nature, and upregulation of vimentin was suggestive of epithelial-mesenchymal transition. The most distinctive finding was a loss of E-cadherin expression within the discohesive cells, accompanied by increased cytosolic expression of β-catenin.
Conclusions
This report presents the histomorphologic features of a unique form of oral epithelial dysplasia, termed adenoid dysplasia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | �© 2014 Elsevier Inc. All rights reserved |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 Jul 2015 10:15 |
Last Modified: | 26 Oct 2015 18:29 |
Published Version: | http://dx.doi.org/10.1016/j.oooo.2014.08.009 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.oooo.2014.08.009 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87884 |