Williams, TJ, Bray, JTW, Lake, BRM et al. (7 more authors) (2015) Mechanistic Elucidation of the Arylation of Non-Spectator N-Heterocyclic Carbenes at Copper using a Combined Experimental and Computational Approach. Organometallics, 34 (14). pp. 3497-3507. ISSN 0276-7333
Abstract
CuI(NHC)Br complexes (NHC = N-heterocyclic carbene) undergo a direct reaction with iodobenzene to give 2-arylated benzimidazolium products. The nature of the Nsubstituent on the NHC ligand influences the reactivity of the CuI(NHC)Br complex towards arylation. N-Benzyl or Nphenyl substituents facilitate arylation, whereas N-mesityl substituents hinder arylation. Density functional theory calculations show that an oxidative addition/reductive elimination pathway, involving CuIII species, is energetically feasible. A less hindered CuI(NHC)Br complex, with N-benzyl groups, is susceptible to oxidation reactions to give 1,3- dibenzylbenzimidazolium cations containing a CuIBrx anion (various polymorphs). The results described herein are of relevance to C-H functionalization of benz(azoles).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organometallics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.organomet.5b00093 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Jul 2015 12:39 |
Last Modified: | 13 Jul 2016 19:03 |
Published Version: | http://dx.doi.org/10.1021/acs.organomet.5b00093 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.organomet.5b00093 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87872 |