Dave, RV, Jebar, AHS, Jennings, VA et al. (5 more authors) (2014) Viral warfare! Front-line defence and arming the immune system against cancer using oncolytic vaccinia and other viruses. Surgeon, 12 (4). 210 - 220. ISSN 1479-666X
Abstract
Background: Despite mankind's many achievements, we are yet to find a cure for cancer. We are now approaching a new era which recognises the promise of harnessing the immune system for anti-cancer therapy. Pathogens have been implicated for decades as potential anti-cancer agents, but implementation into clinical therapy has been plagued with significant drawbacks. Newer 'designer' agents have addressed some of these concerns, in particular, a new breed of oncolytic virus: JX-594, a genetically engineered pox virus, is showing promise. Objective: To review the current literature on the use of oncolytic viruses in the treatment of cancer; both by direct oncolysis and stimulation of the immune system. The review will provide a background and historical progression for the surgeon on tumour immunology, and the interplay between oncolytic viruses, immune cells, inflammation on tumourigenesis. Methods: A literature review was performed using the Medline database. Conclusions: Viral therapeutics hold promise as a novel treatment modality for the treatment of disseminated malignancy. It provides a multi-pronged attack against tumour burden; direct tumour cell lysis, exposure of tumour-associated antigens (TAA), induction of immune danger signals, and recognition by immune effector cells.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Oncolytic virus; JX-594; Reovirus; Tumour immunology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Oct 2015 08:48 |
Last Modified: | 25 Oct 2015 23:29 |
Published Version: | http://dx.doi.org/10.1016/j.surge.2014.01.001 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.surge.2014.01.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87578 |