Waby, J.S., Bingle, C.D. orcid.org/0000-0002-5405-6988 and Corfe, B.M. orcid.org/0000-0003-0449-2228 (2008) Post-translational control of Sp-family transcription factors. Current Genomics, 9 (5). pp. 301-311. ISSN 1389-2029
Abstract
Sp-family transcription factors are widely expressed in human tissues and involved in the regulation of many cellular processes and response to cellular microenvironment. These responses appear to be mediated by alterations in transcription factor affinity for DNA rather than altered protein level. How might such changes be effected? This review will identify the range of known post-translational modifications (PTMs) of Sp-factors and the sometimes conflicting literature about the roles of PTMs in regulating activity. We will speculate on the interaction between cell environment, chromatin microenvironment and the role of PTM in governing functionality of the proteins and the complexes to which they belong.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2008 Bentham Science. |
Keywords: | Sp family; Sp1; Sp3 phosphorylation; acetylation; glycosylation; sumolation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 May 2020 07:10 |
Last Modified: | 12 May 2020 07:10 |
Status: | Published |
Publisher: | Bentham Science |
Refereed: | Yes |
Identification Number: | 10.2174/138920208785133244 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87479 |