Natali, AJ, Fowler, ED, Calaghan, S orcid.org/0000-0002-9145-2576 et al. (1 more author) (2015) Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension. AJP - Heart and Circulatory Physiology, 309 (3). H421-H424. ISSN 0363-6135
Abstract
Increased physical activity is recommended for the general population and to patients of many diseases because of its health benefits but can be contraindicated if it is thought a risk for serious cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT rats with voluntary access to a running wheel ran on average 2km per day. The time for half the animals to develop heart failure signs (median survival time) was 28 days (exercise failure (EF) group), significantly longer than sedentary animals (sedentary failure (SF) group), 23 days). The contractility of single failing myocytes in response to increasing demand (stimulation frequency) was significantly impaired compared with both sedentary control (SC) and exercising control (EC) myocytes. However, myocytes from exercising MCT rats, tested at 23 days (EM group) showed responses intermediate to the control (SC, EC) and failing (SF, EF) groups. We conclude that voluntary exercise is beneficial to rats with heart failure induced by PAH and this is evidence to support the consideration of appropriate exercise regimes for potentially vulnerable groups.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, American Physiological Society. This is an author produced version of a paper published in AJP - Heart and Circulatory Physiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | exercise; heart failure; monocrotaline; myocyte |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Jun 2015 11:52 |
Last Modified: | 29 Oct 2020 15:14 |
Published Version: | http://dx.doi.org/10.1152/ajpheart.00262.2015 |
Status: | Published |
Publisher: | American Physiological Society |
Identification Number: | 10.1152/ajpheart.00262.2015 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87262 |