A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids.
Foley, DJ, Doveston, RG, Churcher, I et al. (2 more authors)
(2015)
A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids.
Chemical Communications.
ISSN 1359-7345
Abstract
A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.
Metadata
Item Type:
Article
Authors/Creators:
Foley, DJ
Doveston, RG
Churcher, I
Nelson, A
Marsden, SP
Copyright, Publisher and Additional Information:
(c) 2015, Royal Society of Chemistry. This is an open access article, licensed under a Creative Commons Attribution 3.0 Unported License.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)