Hardie, R.C. and Juusola, M. (2015) Phototransduction in Drosophila. Current Opinion in Neurobiology, 34. 37 - 45. ISSN 0959-4388
Abstract
Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca(2+)-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically activated by physical effects of PIP2 depletion on the membrane, in combination with protons released by PLC. We also review molecularly explicit models indicating how Ca(2+)-dependent positive and negative feedback along with the ultracompartmentalization provided by the microvillar design can account for the ability of fly photoreceptors to respond to single photons 10-100× more rapidly than vertebrate rods, yet still signal under full sunlight.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2015 Elsevier. This is an author produced version of a paper subsequently published in Current Opinion in Neurobiology. Uploaded in accordance with the publisher's self-archiving policy. This article is distributed under the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/3.0/) |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
| Depositing User: | Symplectic Sheffield |
| Date Deposited: | 06 Jul 2015 09:07 |
| Last Modified: | 31 Jul 2015 04:41 |
| Published Version: | http://dx.doi.org/10.1016/j.conb.2015.01.008 |
| Status: | Published |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Identification Number: | 10.1016/j.conb.2015.01.008 |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87060 |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)