Pepper, E and Cardno, AG (2014) Genetics of schizophrenia and other psychotic disorders. Current Psychiatry Reviews, 10 (2). 133 - 142. ISSN 1573-4005
Abstract
Research into the genetic basis of schizophrenia is advancing rapidly. This review gives a broad overview of results from successive phases of studies in this field, linking these with recent findings and likely future research directions. Among recent findings, large-scale epidemiological studies based on Scandinavian population registers, have provided further evidence of substantial heritability and evidence that a wide range of psychotic and non-psychotic disorders partly share genetic risk factors with schizophrenia. In molecular genetics, large collaborative genomewide association studies (GWAS) are providing evidence of common risk variants, each of small effect, and many more variants are likely to be found as samples sizes increase further. A range of rarer chromosomal copy number variants (CNVs) have been associated with schizophrenia, and both GWAS and CNV studies have provided molecular evidence of genetic overlap between schizophrenia and other disorders. There is increasing interest in phenotypes beyond diagnosis, including further clinical variables and endophenotypes. Next-generation sequencing studies are beginning, with the potential for fast, inexpensive sequencing of the whole genome in large samples, and there is an increasing focus on the functional effects of the candidate risk variants that are being identified.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014, Bentham Science. This is an author produced version of a paper published in Current Psychiatry Reviews. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Endophenotype; genetics; GWAS; heritability; linkage; psychosis; schizoaffective; schizophrenia |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Aug 2015 10:51 |
Last Modified: | 16 Jan 2018 04:41 |
Published Version: | http://dx.doi.org/10.2174/157340051066614031923554... |
Status: | Published |
Publisher: | Bentham Science |
Identification Number: | 10.2174/1573400510666140319235545 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87019 |