Cardno, AG and Owen, MJ (2014) Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder. Schizophrenia Bulletin, 40 (3). 504 - 515. ISSN 0586-7614
Abstract
There is substantial evidence for partial overlap of genetic influences on schizophrenia and bipolar disorder, with family, twin, and adoption studies showing a genetic correlation between the disorders of around 0.6. Results of genome-wide association studies are consistent with commonly occurring genetic risk variants, contributing to both the shared and nonshared aspects, while studies of large, rare chromosomal structural variants, particularly copy number variants, show a stronger influence on schizophrenia than bipolar disorder to date. Schizoaffective disorder has been less investigated but shows substantial familial overlap with both schizophrenia and bipolar disorder. A twin analysis is consistent with genetic influences on schizoaffective episodes being entirely shared with genetic influences on schizophrenic and manic episodes, while association studies suggest the possibility of some relatively specific genetic influences on broadly defined schizoaffective disorder, bipolar subtype. Further insights into genetic relationships between these disorders are expected as studies continue to increase in sample size and in technical and analytical sophistication, information on phenotypes beyond clinical diagnoses are increasingly incorporated, and approaches such as next-generation sequencing identify additional types of genetic risk variant.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014, The Author. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Schizophr Bull (2014) 40 (3): 504-515, is available online at: http://dx.doi.org/10.1093/schbul/sbu016 |
Keywords: | GWAS; Adoption; Copy number variants; Family studies; Twin; Adoption; Bipolar Disorder; DNA Copy Number Variations; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Phenotype; Psychotic Disorders; Schizophrenia; Twins |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2015 15:42 |
Last Modified: | 16 Jan 2018 05:33 |
Published Version: | http://dx.doi.org/10.1093/schbul/sbu016 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/schbul/sbu016 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87017 |