Beales, PA and Vanderlick, TK (2014) Application of nucleic acid-lipid conjugates for the programmable organisation of liposomal modules. Advances in Colloid and Interface Science, 207 (Helmut). 290 - 305. ISSN 0001-8686
Abstract
We present a critical review of recent work related to the assembly of multicompartment liposome clusters using nucleic acids as a specific recognition unit to link liposomal modules. The asymmetry in nucleic acid binding to its non-self complementary strand allows the controlled association of different compartmental modules into composite systems. These biomimetic multicompartment architectures could have future applications in chemical process control, drug delivery and synthetic biology. We assess the different methods of anchoring DNA to lipid membrane surfaces and discuss how lipid and DNA properties can be tuned to control the morphology and properties of liposome superstructures. We consider different methods for chemical communication between the contents of liposomal compartments within these clusters and assess the progress towards making this chemical mixing efficient, switchable and chemically specific. Finally, given the current state of the art, we assess the outlook for future developments towards functional modular networks of liposomes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014, Elsevier B.V. All rights reserved. This is an author produced version of a paper published in Advances in Colloid and Interface Science. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bionanotechnology; Compartmentalization; DNA amphiphiles; Directed assembly; Lipid vesicles |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Physical Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2015 15:23 |
Last Modified: | 20 Oct 2015 12:54 |
Published Version: | http://dx.doi.org/10.1016/j.cis.2013.12.009 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cis.2013.12.009 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87004 |