Ieva, F, Gale, CP and Sharples, LD (2014) Contemporary roles of registries in clinical cardiology: When do we need randomized trials? Expert Review of Cardiovascular Therapy, 12 (12). 1383 - 1386. ISSN 1477-9072
Abstract
Clinical registries are established as tools for auditing clinical standards and benchmarking quality improvement initiatives. They also have an emerging role (as electronic health records) in cardiovascular research and, in particular, the conduct of RCTs. While the RCT is accepted as the most robust experimental design, observational data from clinical registries has become increasingly valuable for RCTs. Data from clinical registries may be used to augment results from RCTs, identify patients for recruitment and as an alternative when randomization is not practically possible or ethically desirable. Here the authors appraise the advantages and disadvantages of both methodologies, with the aim of clarifying when their joint use may be successful.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014, Informa. This is an author produced version of a paper published in Expert Review of Cardiovascular Therapy. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | clinical cardiology, clinical practice, clinical registries, evidence based medicine, observational data, randomized controlled trials, routinely collected data |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jul 2015 13:18 |
Last Modified: | 13 Apr 2017 00:34 |
Published Version: | http://dx.doi.org/10.1586/14779072.2015.982096 |
Status: | Published |
Identification Number: | 10.1586/14779072.2015.982096 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86986 |